tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain (TNFRSF10D) - coding DNA reference sequence

(used for mutation description)

(last modified May 2, 2012)


This file was created to facilitate the description of sequence variants in the TNFRSF10D gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032579.1, covering TNFRSF10D transcript NM_003840.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5032
                          ggcagtgtagctgcgagaacctttgcacgcgcaca       c.-61

 .         .         .         .         .         .                g.5092
 aactacggggacgatttctgattgatttttggcgctttcgatccaccctcctcccttctc       c.-1

          .         .         .         .         .         .       g.5152
 ATGGGACTTTGGGGACAAAGCGTCCCGACCGCCTCGAGCGCTCGAGCAGGGCGCTATCCA       c.60
 M  G  L  W  G  Q  S  V  P  T  A  S  S  A  R  A  G  R  Y  P         p.20

          .         .         .         .         .         .       g.5212
 GGAGCCAGGACAGCGTCGGGAACCAGACCATGGCTCCTGGACCCCAAGATCCTTAAGTTC       c.120
 G  A  R  T  A  S  G  T  R  P  W  L  L  D  P  K  I  L  K  F         p.40

          .         .         . | 02       .         .         .    g.14078
 GTCGTCTTCATCGTCGCGGTTCTGCTGCCG | GTCCGGGTTGACTCTGCCACCATCCCCCGG    c.180
 V  V  F  I  V  A  V  L  L  P   | V  R  V  D  S  A  T  I  P  R      p.60

          .         .         .         .         .         .       g.14138
 CAGGACGAAGTTCCCCAGCAGACAGTGGCCCCACAGCAACAGAGGCGCAGCCTCAAGGAG       c.240
 Q  D  E  V  P  Q  Q  T  V  A  P  Q  Q  Q  R  R  S  L  K  E         p.80

          .       | 03 .         .         .         .         .    g.20520
 GAGGAGTGTCCAGCAG | GATCTCATAGATCAGAATATACTGGAGCCTGTAACCCGTGCACA    c.300
 E  E  C  P  A  G |   S  H  R  S  E  Y  T  G  A  C  N  P  C  T      p.100

          .         .         .         .         .         .       g.20580
 GAGGGTGTGGATTACACCATTGCTTCCAACAATTTGCCTTCTTGCCTGCTATGTACAGTT       c.360
 E  G  V  D  Y  T  I  A  S  N  N  L  P  S  C  L  L  C  T  V         p.120

          . | 04       .         .         .         .         .    g.22005
 TGTAAATCAG | GTCAAACAAATAAAAGTTCCTGTACCACGACCAGAGACACCGTGTGTCAG    c.420
 C  K  S  G |   Q  T  N  K  S  S  C  T  T  T  R  D  T  V  C  Q      p.140

          .         .         .         .         .         .       g.22065
 TGTGAAAAAGGAAGCTTCCAGGATAAAAACTCCCCTGAGATGTGCCGGACGTGTAGAACA       c.480
 C  E  K  G  S  F  Q  D  K  N  S  P  E  M  C  R  T  C  R  T         p.160

    | 05     .         .         .         .         .         .    g.23164
 GG | GTGTCCCAGAGGGATGGTCAAGGTCAGTAATTGTACGCCCCGGAGTGACATCAAGTGC    c.540
 G  |  C  P  R  G  M  V  K  V  S  N  C  T  P  R  S  D  I  K  C      p.180

          .         .         .         .         .         .       g.23224
 AAAAATGAATCAGCTGCCAGTTCCACTGGGAAAACCCCAGCAGCGGAGGAGACAGTGACC       c.600
 K  N  E  S  A  A  S  S  T  G  K  T  P  A  A  E  E  T  V  T         p.200

          .         .         .         .         .         .       g.23284
 ACCATCCTGGGGATGCTTGCCTCTCCCTATCACTACCTTATCATCATAGTGGTTTTAGTC       c.660
 T  I  L  G  M  L  A  S  P  Y  H  Y  L  I  I  I  V  V  L  V         p.220

          .         .         .         .         .         .       g.23344
 ATCATTTTAGCTGTGGTTGTGGTTGGCTTTTCATGTCGGAAGAAATTCATTTCTTACCTC       c.720
 I  I  L  A  V  V  V  V  G  F  S  C  R  K  K  F  I  S  Y  L         p.240

          .       | 06 .         .         .         | 07         . g.24404
 AAAGGCATCTGCTCAG | GTGGTGGAGGAGGTCCCGAACGTGTGCACAGA | GTCCTTTTCCGG c.780
 K  G  I  C  S  G |   G  G  G  G  P  E  R  V  H  R   | V  L  F  R   p.260

          .         .         .         .         .         .       g.24464
 CGGCGTTCATGTCCTTCACGAGTTCCTGGGGCGGAGGACAATGCCCGCAACGAGACCCTG       c.840
 R  R  S  C  P  S  R  V  P  G  A  E  D  N  A  R  N  E  T  L         p.280

          .         .         .         .         .         .       g.24524
 AGTAACAGATACTTGCAGCCCACCCAGGTCTCTGAGCAGGAAATCCAAGGTCAGGAGCTG       c.900
 S  N  R  Y  L  Q  P  T  Q  V  S  E  Q  E  I  Q  G  Q  E  L         p.300

          .         .         .         .         .     | 08   .    g.30773
 GCAGAGCTAACAGGTGTGACTGTAGAGTTGCCAGAGGAGCCACAGCGTCTGCTG | GAACAG    c.960
 A  E  L  T  G  V  T  V  E  L  P  E  E  P  Q  R  L  L   | E  Q      p.320

          .         .         .         .         .         .       g.30833
 GCAGAAGCTGAAGGGTGTCAGAGGAGGAGGCTGCTGGTTCCAGTGAATGACGCTGACTCC       c.1020
 A  E  A  E  G  C  Q  R  R  R  L  L  V  P  V  N  D  A  D  S         p.340

         | 09.         .         .         .         .         .    g.31077
 GCTGACA | TCAGCACCTTGCTGGATGCCTCGGCAACACTGGAAGAAGGACATGCAAAGGAA    c.1080
 A  D  I |   S  T  L  L  D  A  S  A  T  L  E  E  G  H  A  K  E      p.360

          .         .         .         .         .         .       g.31137
 ACAATTCAGGACCAACTGGTGGGCTCCGAAAAGCTCTTTTATGAAGAAGATGAGGCAGGC       c.1140
 T  I  Q  D  Q  L  V  G  S  E  K  L  F  Y  E  E  D  E  A  G         p.380

          .         .                                               g.31158
 TCTGCTACGTCCTGCCTGTGA                                              c.1161
 S  A  T  S  C  L  X                                                p.386

          .         .         .         .         .         .       g.31218
 aagaatctcttcaggaaaccagagcttccctcatttaccttttctcctacaaagggaagc       c.*60

          .         .         .         .         .         .       g.31278
 agcctggaagaaacagtccagtacttgacccatgccccaacaaactctactatccaatat       c.*120

          .         .         .         .         .         .       g.31338
 ggggcagcttaccaatggtcctagaactttgttaacgcacttggagtaatttttatgaaa       c.*180

          .         .         .         .         .         .       g.31398
 tactgcgtgtgataagcaaacgggagaaatttatatcagattcttggctgcatagttata       c.*240

          .         .         .         .         .         .       g.31458
 cgattgtgtattaagggtcgttttaggccacatgcggtggctcatgcctgtaatcccagc       c.*300

          .         .         .         .         .         .       g.31518
 actttgataggctgaggcaggtggattgcttgagctcgggagtttgagaccagcctcatc       c.*360

          .         .         .         .         .         .       g.31578
 aacacagtgaaactccatctcaatttaaaaagaaaaaaagtggttttaggatgtcattct       c.*420

          .         .         .         .         .         .       g.31638
 ttgcagttcttcatcatgagacaagtctttttttctgcttcttatattgcaagctccatc       c.*480

          .         .         .         .         .         .       g.31698
 tctactggtgtgtgcatttaatgacatctaactacagatgccgcacagccacaatgcttt       c.*540

          .         .         .         .         .         .       g.31758
 gccttatagttttttaactttagaacgggattatcttgttattacctgtattttcagttt       c.*600

          .         .         .         .         .         .       g.31818
 cggatatttttgacttaatgatgagattatcaagacgtagccctatgctaagtcatgagc       c.*660

          .         .         .         .         .         .       g.31878
 atatggacttacgagggttcgacttagagttttgagctttaagataggattattggggct       c.*720

          .         .         .         .         .         .       g.31938
 tacccccaccttaattagagaaacatttatattgcttactactgtaggctgtacatctct       c.*780

          .         .         .         .         .         .       g.31998
 tttccgatttttgtataatgatgtaaacatggaaaaactttaggaaatgcacttattagg       c.*840

          .         .         .         .         .         .       g.32058
 ctgtttacatgggttgcctggatacaaatcagcagtcaaaaatgactaaaaatataacta       c.*900

          .         .         .         .         .         .       g.32118
 gtgacggagggagaaatcctccctctgtgggaggcacttactgcattccagttctccctc       c.*960

          .         .         .         .         .         .       g.32178
 ctgcgccctgagactggaccagggtttgatggctggcagcttctcaaggggcagcttgtc       c.*1020

          .         .         .         .         .         .       g.32238
 ttacttgttaattttagaggtatatagccatatttatttataaataaatatttatttatt       c.*1080

          .         .         .         .         .         .       g.32298
 tatttataagtagatgtttacatatgcccaggattttgaagagcctggtatctttgggaa       c.*1140

          .         .         .         .         .         .       g.32358
 gccatgtgtctggtttgtcgtgctgggacagtcatgggactgcatcttccgacttgtcca       c.*1200

          .         .         .         .         .         .       g.32418
 cagcagatgaggacagtgagaattaagttagatccgagactgcgaagagcttctctttca       c.*1260

          .         .         .         .         .         .       g.32478
 agcgccattacagttgaacgttagtgaatcttgagcctcatttgggctcagggcagagca       c.*1320

          .         .         .         .         .         .       g.32538
 ggtgtttatctgccccggcatctgccatggcatcaagagggaagagtggacggtgcttgg       c.*1380

          .         .         .         .         .         .       g.32598
 gaatggtgtgaaatggttgccgactcaggcatggatgggcccctctcgcttctggtggtc       c.*1440

          .         .         .         .         .         .       g.32658
 tgtgaactgagtccctgggatgccttttagggcagagattcctgagctgcgttttagggt       c.*1500

          .         .         .         .         .         .       g.32718
 acagattccctgtttgaggagcttggcccctctgtaagcatctgactcatctcagagata       c.*1560

          .         .         .         .         .         .       g.32778
 tcaattcttaaacactgtgacaacaggatctaaaatggctgacacatttgtccttgtgtc       c.*1620

          .         .         .         .         .         .       g.32838
 acgttccattattttatttaaaaacctcagtaatcgttttagcttctttccagcaaactc       c.*1680

          .         .         .         .         .         .       g.32898
 ttctccacagtagcccagtcgtggtaggataaattacggatatagtcattctaggggttt       c.*1740

          .         .         .         .         .         .       g.32958
 cagtcttttccatctcaaggcattgtgtgttttgttccgggactggtttggctgggacaa       c.*1800

          .         .         .         .         .         .       g.33018
 agttagaactgcctgaagttcgcacattcagattgttgtgtccatggagttttaggaggg       c.*1860

          .         .         .         .         .         .       g.33078
 gatggcctttccggtcttcgcacttccatcctctcccacttccatctggcgtcccacacc       c.*1920

          .         .         .         .         .         .       g.33138
 ttgtcccctgcacttctggatgacacagggtgctgctgcctcctagtctttgcctttgct       c.*1980

          .         .         .         .         .         .       g.33198
 gggccttctgtgcaggagacttggtctcaaagctcagagagagccagtccggtcccagct       c.*2040

          .         .         .         .         .         .       g.33258
 cctttgtcccttcctcagaggccttccttgaagatgcatctagactaccagccttatcag       c.*2100

          .         .         .         .         .         .       g.33318
 tgtttaagcttattcctttaacataagcttcctgacaacatgaaattgttggggtttttt       c.*2160

          .         .         .         .         .         .       g.33378
 ggcgttggttgatttgtttaggttttgctttatacccgggccaaatagcacataacacct       c.*2220

          .         .         .         .         .         .       g.33438
 ggttatatatgaaatactcatatgtttatgaccaaaataaatatgaaacctcatattaaa       c.*2280

                                                                    g.33440
 aa                                                                 c.*2282

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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