LOVD - Variant listings for TNFRSF10A

About this overview [Show]

Patient data (#0000059)
Patient ID
Disease Lung cancer and Head and Neck Cancer
Reference Fisher et al., 2001
Template DNA
Technique DGGE, PCR
Frequency -
Remarks A number of samples from four different cancer types were sequenced for these polymorphisms. Variants 626G>C and 422A>G may be associated with an increase in predisposition to cancer types.

Variant data
Allele Unknown
Reported pathogenicity Unknown
Concluded pathogenicity Unknown
External ID dbSNP
Exon 10
DNA change c.1322G>A   (View in UCSC Genome Browser, Ensembl)
Type Substitution
Mutation effect Missense
Protein p.(Arg441Lys)
PolyPhen 2 Benign
Frequency -
DB-ID TNFRSF10A_00001

3 entries in TNFRSF10A

Path.
Allele Descending
Ascending
External ID Descending
Ascending
Exon Descending
Ascending
DNA change Descending
Ascending
Type Descending
Ascending
Mutation effect Descending
Ascending
Protein Descending
Ascending
PolyPhen 2 Descending
Ascending
Frequency Descending
Ascending
DB-ID Descending
Ascending
?/? Unknown dbSNP 3 c.422A>G Substitution Missense p.(His141Arg) Possibly damaging - TNFRSF10A_00002
?/? Unknown dbSNP 4 c.626G>C Substitution Missense p.(Arg209Thr) Benign - TNFRSF10A_00003
?/? Unknown dbSNP 10 c.1322G>A Substitution Missense p.(Arg441Lys) Benign - TNFRSF10A_00001